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Precision Reproductive Science & Diagnostics
From Sample Collection to Molecular Service
Norgen Biotek offers room-temperature solutions to preserve samples, maintaining the stability and quality of DNA, RNA, and circulating nucleic acids over long distances. Discover our kits for isolating and purifying DNA/RNA, exosomes, miRNA, and cf-DNA/cf-RNA, designed to maximize yield, reduce errors, and support NIPT, niPGT, and advanced reproductive research.
The quality of the biological sample determines the success of molecular analyses and, consequently, clinical decisions and pregnancy rates. DNA degradation, RNA instability, and variability introduced during sampling, transport, and storage can compromise test sensitivity, increase “no-call” rates, and limit innovation in ART and non-invasive diagnostics.
Norgen Biotek offers a comprehensive platform designed for critical reproductive matrices: maternal blood, plasma, urine, vaginal microbiome, stool, and embryonic fluids. From ambient-temperature collection and preservation, to ultra-selective purification of cf-DNA, cf-RNA, and exosomes, and on to end-to-end support for NGS and qPCR, our solutions enable you to:
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Minimize analytical failures
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Maximize recovery from minimal input volumes (oocytes, plasma, spent culture media)
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Standardize workflows across multiple sites
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Accelerate the development of clinical biomarkers (niPGT, NIPT, embryo competence indicators)
Following below, you will find the ideal solutions for your lab or clinic, from standardization across multiple sites and reduced sample failures, to advanced biomarker development for niPGT, NIPT, and next-generation fertility medicine.
Key Solutions for Fertility Clinics & Reproductive Research Centers
Degradation of maternal samples (blood, urine, vaginal swabs, stool) during collection,
transport, and storage compromises molecular testing accuracy, causing no-call results, false negatives and loss of critical patient stratification data.
Norgen Biotek's ambient preservation solutions for microbiome profiling, genetic screening and reproductive health assessment,
ensure total nucleic acid integrity from all maternal matrices for 30+ days at room temperature, eliminating technical delays and maximizing embryo transfer success.
Total Nucleic Acid Preservation Tubes Dx
Designed for ambient preservation and transport of nucleic acid (DNA and RNA) from samples collected using a swab.
- CE-IVDR marked in accordance with the European Commission Regulation (EU) No. 2017/746. Ideal for use in in vitro diagnostic workflows.
- No need to immediately process samples.
- Total DNA, including viral DNA, preserved at room temperature over 4 months.
- Total RNA, including viral RNA, preserved at room temperature over 2 months.
- Inactivate microorganisms including bacteria, fungi, yeast and viruses.
- Ship swab samples at room temperature safely.
- Compatible with most DNA and RNA isolation methods.
SKU Dx69200 | 50 Tubes
USD$359.00
Norgen’s Total Nucleic Acid Preservation Tubes are designed for ambient preservation and transport of total nucleic acids (DNA and RNA) from samples collected using a swab
cf-DNA / cf-RNA Preservative Tubes
Engineered to inhibit metabolic degradation and cellular lysis, preserving the delicate cell-free nucleic acid profile.
- Intended also for in vitro diagnostic workflows. CE-IVD marked in accordance with EU Directive 98/79/EC.
- Fixative-free preservative, no cross-linking of DNA.
- Preserve cf-DNA/ct-DNA for 30 days at ambient temperature and for up to 8 days at 37°C.
- Preserve cf-RNA for 30 days at ambient temperature.
- No plasma volume loss after shipping transportation.
- Prevent hemolysis of blood cells and fragmentation of genomic DNA.
- Produce high quality/quantity of plasma cf-DNA/ct-DNA/cf-RNA.
- The procedure for plasma isolation using this kit is compliant with ISO 20186-3:2019.
- Unrivaled Consistency: Standardizes sample quality across multiple collection sites, reducing "no-call" rates and improving the reproducibility of NGS and qPCR results.
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SKU Dx63950 | 50 Tubes
USD$541.00
For Whole Blood Collection and Preservation of Cell-Free Circulating DNA and RNA
Urine Collection and Preservation Tubes
Designed to slow the degradation of macromolecules and may reduce the need to immediately process or freeze samples and thus allows the sample to be shipped to centralized testing facilities at ambient temperatures.
- Macromolecules can be stabilized at room temperature.
- Compatible with many nucleic acid and protein purification methods.
- Available in a dried format tubes and 4 convenient sizes.
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SKU 18113 | 50 cc | 50 Tubes
USD$648.00
For rapid and simple collection, and preservation of urine samples
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SKU 18118 | 5 cc | 50 Tubes
USD$541.00
For rapid and simple collection, and preservation of urine samples
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Sample Available
SKU 18122 | 15 cc | 50 Tubes
USD$596.00
For rapid and simple collection, and preservation of urine samples
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Sample Available
SKU 18126 | Single Dose Preservative | 50 Ampules
USD$483.00
For rapid and simple collection, and preservation of urine samples
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SKU 18129 | 120 cc Cup | 1 Cup
USD$15.00
For rapid and simple collection, and preservation of urine samples
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SKU 18113 | 50 cc | 50 Tubes
USD$648.00
For rapid and simple collection, and preservation of urine samples
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SKU 18118 | 5 cc | 50 Tubes
USD$541.00
For rapid and simple collection, and preservation of urine samples
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Sample Available
SKU 18122 | 15 cc | 50 Tubes
USD$596.00
For rapid and simple collection, and preservation of urine samples
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Sample Available
SKU 18126 | Single Dose Preservative | 50 Ampules
USD$483.00
For rapid and simple collection, and preservation of urine samples
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SKU 18129 | 120 cc Cup | 1 Cup
USD$15.00
For rapid and simple collection, and preservation of urine samples
Stool Nucleic Acid Collection and Preservation Tubes
For rapid and simple collection, preservation and room temperature shipping of stool samples.
- Intended also for in vitro diagnostic workflows. Complies with European Commission Regulation (EU) No. 2017/746.
- Stable preservation for over 2 years for DNA and 7 days at room temperature.
- Eliminates sample variability.
- Renders the sample non-infectious by preventing bacterial/fungal growth and inactivating viruses.
- A reliable and reproducible source of sample for microbial detection or metagenomics analysis via applications including PCR, NGS and microarray analysis.
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Sample Available
SKU 45660 | 50 Tubes
USD$757.00
A rapid and simple method for the collection, preservation and room temperature shipping of stool samples.
In reproductive and developmental biology, research breakthroughs depend on recovering pure, intact nucleic acids from the most delicate, low-yield samples such as oocytes, cumulus cells, seminal plasma, follicular fluid and embryo-conditioned media. Norgen Biotek delivers extraction technologies that provide full-spectrum DNA/RNA purification with exceptional sensitivity and purity, yielding NGS/qPCR-ready material.
Total RNA Purification Kits
Comprehensive RNA purification from reproductive fluids and cells
- Capture complete spectrum including small RNAs and microRNAs without using phenol/chloroform.
- Rapid spin column technology using only standard lab centrifuges: no specialized equipment required.
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Best Seller
SKU 37500 | Spin Column | 100 Preps
USD$520.00
For the rapid purification of total RNA - including microRNA - without the use of phenol
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Best Seller
Sample Available
SKU 17200 | Spin Column | 50 Preps
USD$283.00
For the rapid purification of total RNA - including microRNA - without the use of phenol
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SKU 17250 | Spin Column | 250 Preps
USD$1,190.00
For the rapid purification of total RNA - including microRNA - without the use of phenol
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SKU 17270 | Spin Column | 500 Preps
USD$2,162.00
For the rapid purification of total RNA - including microRNA - without the use of phenol
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SKU Dx17200 | Spin Column | 50 Preps
USD$298.00
For the isolation and purification of total RNA from tissue samples, blood, plasma, serum, bacteria, yeast, fungi and viruses for subsequent in vitro diagnostic use
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Best Seller
SKU 37500 | Spin Column | 100 Preps
USD$520.00
For the rapid purification of total RNA - including microRNA - without the use of phenol
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Best Seller
Sample Available
SKU 17200 | Spin Column | 50 Preps
USD$283.00
For the rapid purification of total RNA - including microRNA - without the use of phenol
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SKU 17250 | Spin Column | 250 Preps
USD$1,190.00
For the rapid purification of total RNA - including microRNA - without the use of phenol
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SKU 17270 | Spin Column | 500 Preps
USD$2,162.00
For the rapid purification of total RNA - including microRNA - without the use of phenol
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SKU Dx17200 | Spin Column | 50 Preps
USD$298.00
For the isolation and purification of total RNA from tissue samples, blood, plasma, serum, bacteria, yeast, fungi and viruses for subsequent in vitro diagnostic use
Single Cell RNA Purification Kits
Ultrasensitive and rapid purification of Total RNA including microRNA from small input amounts
- Single oocyte resolution: transcriptomic signatures from individual oocytes (no pooling required).
- Ultra low input as a single cell and up to 100,000 cells.
- Captures RNA and microRNA from oocytes, cumulus cells and granulosa cells derived from a single oocyte.
- Rapid spin column technology using only standard lab centrifuges: no specialized equipment required.
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Best Seller
SKU 74900 | Spin Column | 50 Preps
USD$551.00
Rapid purification of total RNA - including microRNA - from small input amounts
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Best Seller
SKU 51800 | Spin Column | 50 Preps
USD$442.00
Rapid purification of total RNA - including microRNA - from small input amounts
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Best Seller
SKU 74900 | Spin Column | 50 Preps
USD$551.00
Rapid purification of total RNA - including microRNA - from small input amounts
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Best Seller
SKU 51800 | Spin Column | 50 Preps
USD$442.00
Rapid purification of total RNA - including microRNA - from small input amounts
Plasma/Serum Circulating and Exosomal RNA Purification Kits
High purity isolation of circulating and exosomal RNA from maternal plasma/serum or other reproductive fluids and spent culture media
- Isolate all sizes of circulating and exosomal RNA, including microRNA.
- Versatile input volumes.
- Concentrate circulating and exosomal RNA into small elution volumes.
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Best Seller
SKU 42800 | Slurry | 50 Preps
USD$555.00
For rapid and simple isolation of circulating RNA including exosomal RNA from plasma/serum samples
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SKU 50900 | Maxi Slurry | 25 Preps
USD$561.00
For rapid and simple isolation of circulating RNA including exosomal RNA from plasma/serum samples
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SKU Dx42800 | Slurry | 50 Preps
USD$633.00
For rapid and simple isolation of circulating RNA including exosomal RNA from plasma/serum samples for in vitro diagnostic use
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SKU 29500 | High Throughput Slurry | 1 x 96-Well Plate
USD$885.00
For rapid and simple isolation of circulating RNA including exosomal RNA from plasma/serum samples
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Best Seller
SKU 42800 | Slurry | 50 Preps
USD$555.00
For rapid and simple isolation of circulating RNA including exosomal RNA from plasma/serum samples
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SKU 50900 | Maxi Slurry | 25 Preps
USD$561.00
For rapid and simple isolation of circulating RNA including exosomal RNA from plasma/serum samples
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SKU Dx42800 | Slurry | 50 Preps
USD$633.00
For rapid and simple isolation of circulating RNA including exosomal RNA from plasma/serum samples for in vitro diagnostic use
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SKU 29500 | High Throughput Slurry | 1 x 96-Well Plate
USD$885.00
For rapid and simple isolation of circulating RNA including exosomal RNA from plasma/serum samples
Norgen Biotek adapts to the specific needs of your clinic or research center, offering two complementary pathways to achieve high-quality molecular results:
- In-House Workflow (Extraction Kits): For laboratories seeking total internal control, we provide optimized kits, such as our Single Cell RNA and cf-DNA Preservative systems, that ensure the highest quality input for sequencing and qPCR, minimizing technical failures even with micro-volume samples.
- Comprehensive Molecular Service (NGS & qPCR): For centers that prefer to outsource complex processing, we offer a full "sample-to-data" service. From expert NGS library preparation to advanced bioinformatics, we manage the technical complexity to deliver clear, actionable data ready for clinical or research interpretation.
- Translational Research Support: We partner with laboratories to bridge the gap between scientific discovery (e.g., novel miRNA biomarkers) and routine application, providing the lot-to-lot consistency required for internal validation and large-scale clinical studies.
- Multi-Site Standardization: Our preservation technologies (e.g., cf-DNA tubes) allow for the harmonization of sample collection across multiple locations, ensuring that all analyzed data, whether processed in-house or through our service, is standardized, comparable, and reliable.
Applications
Traditional Preimplantation Genetic Testing (PGT-A) is the gold standard for aneuploidy screening, employing trophectoderm biopsy (5-10 cells, day-5/6 blastocysts) followed by comprehensive chromosome analysis via NGS or array-CGH. Clinical outcomes demonstrate euploid embryo transfers achieve 60-70% implantation rates vs. 20-30% for untested embryos, significantly reducing miscarriage risk (from 25% to < 5%). However, invasive PGT-A presents well-documented limitations:
- Embryonic stress: Biopsy-induced lysis (3-5% embryo loss), altered metabolism, epigenetic modifications.
- Mosaicism discrepancies: Single-site biopsy (25-50% blastocysts mosaic) ≠ whole-embryo genotype.
- Technical variability: Embryologist skill dependency, biopsy artifacts, DNA amplification bias.
- Workflow constraints: External lab shipping (3-7 days), single-embryo throughput limitation.
Explore new direction in Embryo Liquid Biopsy via Spent Culture Media (SCM) with Norgen Biotek. Recent advances reveal blastocyst-stage embryos actively secrete cell-free DNA (cfDNA)and extracellular vesicles (EVs) into culture media, providing a non-destructive genetic window. Meta-analyses report niPGT cfDNA concordance rates of 80-93% with invasive PGT-A for whole-chromosome aneuploidies, with PPV 85-95% for euploid prediction.
Norgen Biotek Offers a Dual-Biomarker for niPGT
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cfDNA from Spent Culture Media
Embryo-released cfDNA (50-300bp fragments) detectable at 0.1-10 ng/µL concentrations from 10-200 µL SCM. Norgen's Dx55500 cfDNA Purification Micro Kit achieves > 90% recovery of fragmented DNA templates, including < 100bp fragments critical for copy-number variation (CNV) detection.
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SKU 55500 | Micro | 50 PrepsUSD$617.00For rapid and simple purification of cell-free circulating DNA from plasma/serum samples
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SKU Dx55500 | Micro | 50 PrepsUSD$617.00For isolating cell-free circulating DNA (cfc-DNA) from plasma/serum for subsequent in vitro diagnostic use
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SKU 55500 | Micro | 50 PrepsUSD$617.00For rapid and simple purification of cell-free circulating DNA from plasma/serum samples
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SKU Dx55500 | Micro | 50 PrepsUSD$617.00For isolating cell-free circulating DNA (cfc-DNA) from plasma/serum for subsequent in vitro diagnostic use
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Exosomes: Embryo Communication Machinery
Embryos secrete 30-150nm exosomes (CD9+/CD63+/CD81+) containing stable miRNA cargos that reflect developmental competence as viability markers, implantation predictors and aneuploidy signatures. Our solutions:
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Best Seller
Sample AvailableSKU 58000 | Spin Column | 50 PrepsUSD$462.00Quick and easy protocol for the isolation of exosomal RNA from exosomes previously purified using Norgen's Exosome Purification Kits, ultracentrifugation, size-exclusion chromatography or most other commercial methods. This method also enables the sequential isolation of free-circulating RNA from various sample types.
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SKU 55200 | Mini | 50 PrepsUSD$592.00For rapid and simple sequential purification of circulating RNA, exosomal RNA and cell-free circulating DNA from plasma/serum samples
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SKU 72800 | Spin Column | 50 PrepsUSD$520.00For the isolation of exosomal RNA from exosomes previously purified using Norgen's Exosome Purification Kits or Norgen’s EXTRAClean Exosome Purification Kits.
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SKU 75700 | Mini Slurry | 50 PrepsUSD$789.00Quick and easy protocol for the purification of exosomes from different sample type and volumes.
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Best Seller
Sample AvailableSKU 58000 | Spin Column | 50 PrepsUSD$462.00Quick and easy protocol for the isolation of exosomal RNA from exosomes previously purified using Norgen's Exosome Purification Kits, ultracentrifugation, size-exclusion chromatography or most other commercial methods. This method also enables the sequential isolation of free-circulating RNA from various sample types.
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SKU 55200 | Mini | 50 PrepsUSD$592.00For rapid and simple sequential purification of circulating RNA, exosomal RNA and cell-free circulating DNA from plasma/serum samples
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SKU 72800 | Spin Column | 50 PrepsUSD$520.00For the isolation of exosomal RNA from exosomes previously purified using Norgen's Exosome Purification Kits or Norgen’s EXTRAClean Exosome Purification Kits.
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SKU 75700 | Mini Slurry | 50 PrepsUSD$789.00Quick and easy protocol for the purification of exosomes from different sample type and volumes.
Non-Invasive Prenatal Testing (NIPT) analyzes cell-free fetal DNA (cffDNA) from maternal plasma to detect common fetal chromosomal abnormalities, trisomy 21 (Down syndrome), trisomy 18 (Edwards syndrome), trisomy 13 (Patau syndrome), and sex chromosome aneuploidies, from just 10 weeks gestation.
The NIPT Challenge: Sample Quality Determines Success
NIPT accuracy depends entirely on fetal fraction (percentage of cffDNA in total cfDNA). Below 4% fetal fraction, tests fail (no-call results). Common failure causes:
- Maternal cell lysis during blood transport releases genomic DNA, diluting cffDNA
- cfDNA degradation by nucleases destroys shortest fetal fragments (< 100bp)
- Plasma inhibitors block NGS/qPCR performance. Result: 15-20% no-call rates, patient redraws, delayed results, lost revenue
Norgen Biotek's Complete 3-Step NIPT Solution
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Collect and Preserve Your Sample
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Sample AvailableSKU 63950 | 50 TubesUSD$514.00For Whole Blood Collection and Preservation of Cell-Free Circulating DNA and RNA
- Preserve cf-DNA for 30 days at room temperature and ~8 days at 37°C
- No plasma volume loss after transportation
- Prevent hemolysis, and apoptosis of blood cells and fragmentation of genomic DNA High quality and quantity of cf-DNA
- Prevents maternal cell lysis for 30 days at room temperature
- Inhibits nuclease activity, preserves complete cfDNA profile
- No cold chain required, global shipping from any collection site
- CE-IVDR marked Diagnostic (Dx) version available here
Extract cf-DNA from Maternal Blood
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SKU 55600 | Midi | 20 PrepsUSD$417.00For rapid and simple purification of cell-free circulating DNA from plasma/serum samples
- Isolate inhibitor-free cf-DNA (circulating)
- Compatible with Norgen's cf-DNA and Streck cf-DNA BCT® Tubes
- Purification is based on spin column chromatography that uses Norgen's proprietary resin separation matrix.
- CE-IVDR marked Diagnostic (Dx) version available here
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SKU 68000 | Spin Column | 50 PrepsUSD$771.00For rapid and simple purification of all sizes of cell-free circulating DNA (cfc-DNA) and circulating tumour DNA (ct-DNA) from plasma and serum samples
- Versatile plasma and serum input volumes
- Minimal high molecular weight gDNA contamination in the purified cfc-DNA
- Isolate inhibitor-free circulating cf-DNA
- Purify superior quantity and quality DNA in 45 minutes
- Compatible with fresh, preserved or frozen serum/plasma prepared from blood collected on either Norgen's cf-DNA/cf-RNA Preservative Tubes, Cell-Free DNA BCT® (Streck), Heparin, EDTA or Citrate
- Automation capabilities
- Full-spectrum cfDNA recovery (20-10,000 bp fragments)
- Captures ultra-short cffDNA (< 100bp) that competitors miss
- > 95% purity (A260/280), inhibitor-free for direct NGS loading
- 30-minute spin-column protocol, standard centrifuge only
Analysis-Ready
High fetal fraction, ultra-pure cfDNA compatible with all NGS/qPCR NIPT platforms. Prepare DNA Libraries for Sequencing, Next Generation Sequencing and Advanced Bioinformatics Analysis.
Why Reproductive Scientists Choose Norgen
Fertility clinics benefit from Norgen Biotek's support in several ways:
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Improve test accuracy
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Reduce sample failure rates
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Maximize yield from limited material
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Enable advanced molecular diagnostics
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Simplify sample handling and transport
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Support innovation in fertility research
We are ready for tomorrow's challenges. Our technologies are already optimized for exploring new frontiers, supporting clinical research toward comprehensive diagnostics.
Chiara Camerano, PhD
Chiara Camerano is a biotechnologist with a PhD in Cellular and Molecular Biology focused on Reproductive Medicine. Her research centred on the development of an artificial ovary models and the molecular regulation of meiosis and oocyte maturation, with a focus on fertility preservation applications.
Contact Chiara
👉 Because better samples lead to better outcomes.