EXTRAClean Urine microRNA Purification Kit

Features and Benefits

Norgen’s EXTRAClean Urine microRNA Purification Kit provides a rapid method for the isolation and purification of small RNA molecules (< 200 nt) from urine samples. These small RNAs include regulatory RNA molecules such as microRNA (miRNA) as well as tRNA and 5S rRNA. Small RNA molecules are often studied due to their ability to regulate gene expression. Typically miRNAs are 20-25 nucleotides long, and regulate gene expression by binding to mRNA molecules and affecting their stability or translation. MicroRNA expression profiles of different tumor types, relative to their normal tissues, have recently been shown to provide phenotypic signatures for particular cancer types. Unique patterns of aberrant miRNA expression may serve as molecular biomarkers for tumor diagnosis, prognosis of disease specific outcomes, and prediction of therapeutic responses. The small RNA molecules isolated using Norgen’s EXTRAClean Urine microRNA Purification Kit can be used in various downstream applications relating to gene regulation and functional analysis, including RT-PCR, northern blotting and microarray analysis.

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