45 minutes + live Q&A
An accumulation of evidence has shown that exosomes and other extracellular vesicles (EVs) complete cell-to-cell communication by transmitting information to different cells throughout the human body. However, the function and/or physiology of cells can actually be altered upon the transmission of the exosomal contents to a distant or neighbouring cell. Recent research has identified the presence of specific microRNA (miRNA) signatures within exosomes that are related to specific diseases and can be used as biomarkers. Exosomal miRNA profiles have been found to vary significantly depending on the purification or isolation methods used. Therefore, in order to create a reliable RNA profile that could be used as a biomarker, exosome purification and isolation techniques must be taken into consideration since exosomes mainly contain low concentrations of miRNA