Norgen Biotek Corp. has developed a unique platform technology based on a proprietary resin/matrix with many applications including the purification, concentration and clean-up of DNA, RNA and proteins from various specimen types. We have established that our resin has unique reversible binding properties for biomolecules, and is therefore very useful in the separation and purification processes of such molecules. The efficient purification, concentration and fractionation of macromolecules using this technology is already well documented at the analytical scale, and this platform technology will also excel at the industrial scale for a number of reasons. Among these reasons are the following:
1. Multiple cycles use
2. Low manufacturing cost
3. Non-leaching resin
4. Stability of resin under pressure
5. Stability of resin under harsh chemical treatments and temperature
6. The hydrophobic & hydrophilic properties of the resin makes it ideal for both ion exchange and reverse phase chromatography
Norgen holds more than two dozen issued and pending patents, and has successfully exploited part of this extensive IP to develop over 150 sample preparation kits for RNA, DNA, and protein purification for research purposes. These kits are currently being sold to researchers in academia, pharma/biotech companies, and government institutions. Norgen has also demonstrated at the lab bench scale the utility of their resin technology for several industrial applications, including large scale pharmaceutical grade plasmid DNA isolation, filtration and removal of adventitious material, and large scale protein fractionation. These are all lucrative areas, and are available for out licensing.
Norgen’s proprietary technology can be successfully used in industrial processes for removing substances from a liquid by passing said liquid through a filter bed comprised of Norgen’s resin, which is an inexpensive, environmentally-friendly filter media that can easily be regenerated in place and re-used. Norgen’s resin can be used either as a filter bed or as a depth filter, due to the density of the resin. Furthermore, the by-products from the filtration can be successfully recovered from Norgen’s resin. To learn more about the use of Norgen’s technology for industrial scale filtration applications, please contact us.
Norgen’s proprietary technology can be successfully used to purify nucleic acids at the industrial scale. Our sample preparation kits currently isolate microgram to milligram quantities of plasmid DNA, and we have also produced preparative chromatography columns that can isolate gram quantities of plasmid DNA. As our technology is highly scaleable, the isolation of hundreds of grams to kilograms of DNA is very straight forward. The purified plasmid DNA is highly pure, with no contaminating RNA, proteins or genomic DNA, and is also endotoxin free. To learn more about industrial scale purification of plasmid DNA using Norgen’s technology, please contact us.
We have shown that our technology can successfully be used to fractionate plasma and serum proteins using our proprietary resin, including albumin, α-antitrypsin, transferin, haptoglobin, IgG and membrane glycoproteins. We have developed our ProteoSpin™ Serum Depletion Kit based on this technology, and the procedure can easily be scaled up for use at the industrial scale. To learn more about plasma protein fractionation using Norgen’s technology, please contact us.
Norgen’s resin offers distinct advantages over other polymeric resins as it does not collapse under pressure and does not erode in high velocity settings. Norgen has successfully demonstrated that our proprietary technology can be used to fractionate the various proteins found in whey, including major whey proteins such as Beta-lactoglobulin, alpha-lactoglobulin, immunoglobins and BSA, as well as the minor whey proteins also. To learn more about whey protein fractionation using Norgen’s technology, please contact us.
During the industrial manufacturing of some products such as ethanol, expensive enzymes are often required. Typically these enzymes are used once and discarded, resulting in high costs for the process. Norgen’s technology can be used in these processes to capture and purify the enzymes such that they can then be recycled and reused, offering a substantial cost savings. To learn more about enzyme recycling and purification using Norgen’s technology, please contact us.
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