Urine Collection and Preservation Devices
Select each molecule to learn more about Norgen's unique tube and how it separates DNA/RNA from urine samples





Urine Collection and Preservation Devices
Norgen's Urine Collection and Preservation Devices provide a rapid and simple method for the collection, preservation and shipping of urine samples. The Urine Preservative eliminates the need to immediately process or freeze samples and allows the samples to be shipped to centralized testing facilities at ambient temperatures. Nucleic acids and proteins are preserved for more than 2 years at room temperature. Compatible with most DNA/RNA isolation methods.

cf-DNA
Recent evidence indicates that cell-free circulating DNA (cf-DNA) contains valuable information for the discovery of biomarkers that can help with early detection of certain cancer types and for monitoring the disease status. The advantage for using urine as a source for cancer biomarkers is that it can be acquired in large quantities without using invasive procedures. In addition, repeated sampling from the same individual is applicable, which facilitates longitudinal studies. Urine cell-free circulating DNA (cf-DNA) has been utilized for the early diagnosis, prognosis and monitoring of therapy for several cancer types and autoimmune diseases, as well as for investigating fetal DNA that is normally present in the maternal blood. This cf-DNA is usually present as short fragments, generally between 150 and 250 bp or its duplicates, and is derived either from the apoptotic process, necrotic process or from the fetus.
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cf-RNA
Recent evidence indicates that cell-free circulating RNA (cf-RNA) including exosomal RNA in urine contains valuable information for the discovery of biomarkers that can help for the early detection of certain cancer types and for monitoring the disease status as well as for the detection of any infectious pathogens. Cell-free RNA may serve as biomarkers for various diseases including cancer.
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Cellular g-DNA
Many advantages favor the use of urinary DNA for cancer biomarker discovery and diagnosis of different pathogens over the use of blood and tissue samples. DNA found in urine can be divided into 2 basic categories, large, and small. The larger genomic DNA (gDNA) species is generally greater than 1 kb in size, and appears to be derived mainly from exfoliated cells. The second species is smaller, generally between 150 and 250 bp (apoptotic-DNA), and derives, at least in part, from the circulation. The second species is also considered as an RNA/DNA hybrid.
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Exosome
Exosomes are small extracellular vesicles released from cells throughout the body. They are typically between 40-150nm in diameter and act as cellular "messengers", carrying their cargo of proteins, lipids, and cell-free nucleic acids throughout the bloodstream to recipient cells. Since exosomes are released from a variety of cell types, including tumor cells, analyzing their content can provide unique biomarkers for various diseases.
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Micro RNA
Small RNA molecules are often studied due to their ability to regulate gene expression. miRNAs are typically 20-25 nucleotides long, and regulate gene expression by binding to mRNA molecules and affecting their stability or translation. Several recent studies showed that miRNA regulates cell growth and apoptosis.
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Proteins
Urinary proteins are important for many applications such as biomarker discovery, differential expression of proteins in various diseases, and diagnosis. Proper protein concentration prepares the molecules for downstream applications including SDS-PAGE, 2D gels, Whole protein mass spectrometry, MALDI-TOF, LC/MS, Western blotting and Protein microarray.
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Cellular RNA
Urine contains various sizes of RNA; from large mRNA and ribosomal RNA down to small RNAs. These small RNAs include regulatory RNA molecules such as microRNA (miRNA) as well as tRNA and 5S rRNA.
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Features & Benefits
- RNA/microRNA/DNA/Proteins are preserved for more than 2 years at room temperature in Norgen's Urine Preservative
- Compatible with most DNA, Total RNA, microRNA and protein isolation methods
- Preservative is available in a single dose liquid format (ampoule)
- Preservative is also available in a dried format in tubes - Urine Collection and Preservation Tubes
- Convenient and useful for preserving cell-free macromolecules as well as exfoliated cells and microorganisms during shipping of urine at ambient temperatures