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Plasma/Serum Circulating DNA Purification Kits (Slurry Format)

Cat. 50600, 51200, 51300
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Plasma/Serum Circulating DNA Purification Kits (Slurry Format)

Cat. 50600, 51200, 51300

For the rapid and simple isolation of circulating DNA from plasma/serum samples

  • Isolate all sizes of circulating DNA from plasma and serum samples
  • Isolate Viral and Bacterial DNA
  • Versatile plasma and serum input volumes
  • Concentrate circulating DNA into small elution volumes
  • Different elution strategies depending on the downstream application
  • Isolate inhibitor-free circulating DNA for any application including PCR, qPCR, methylation-sensitive PCR
  • Compatible with Streck Cell-Free DNA BCT® Tubes
  • Isolate DNA with high quality and quantity from milk
  • Purification is based on Norgen’s proprietary Silicon Carbide resin matrix

For research use only and NOT intended for in vitro diagnostics.

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Plasma/Serum Circulating DNA Purification Mini Kit (Slurry Format)
(Cat. 50600)
50 preps
Plasma/Serum Circulating DNA Isolation Midi Kit (Slurry Format)
(Cat. 51200)
20 Preps
Plasma/Serum Circulating DNA Isolation Maxi Kit (Slurry Format)
(Cat. 51300)
10 Preps

Product Format
Norgen Biotek offers kits in different standardized formats. You can view and compare kit components in the Components Table in the Product Overview section. For more information on format types, please visit our Format Information page.

Product Size

Kit Specifications

You have selected: Cat. 50600
Kit Specifications
Minimum Plasma/Serum Input
50 μL
Maximum Plasma/Serum Input
400 μL
Minimum Elution Volume
100 μL
Time to Complete Purifications
< 30 minutes


Storage Conditions and Product Stability
All solutions should be kept tightly sealed and stored at room temperature. This kit is stable for 2 years after the date of shipment.

You have selected: Cat. 51200
Kit Specifications
Minimum Plasma/Serum Input
400 μL
Maximum Plasma/Serum Input
2 mL
Minimum Elution Volume
100 μL
Time to Complete Purifications
< 45 minutes


Storage Conditions and Product Stability
It is recommended to warm Slurry C2 and Lysis Buffer A for 20 minutes at 60°C if any salt precipitation is observed. Slurry C2 contains a grey resin that will not dissolve with warming.

You have selected: Cat. 51300
Kit Specifications
Minimum Plasma/Serum Input
2 mL
Maximum Plasma/Serum Input
10 mL
Size of DNA Purified
≥ 50 bp
Elution Volume
100 μL
Time to Complete 10 Purifications
15-20 minutes
Average Yields
Variable depending on specimen

Note: Do not exceed the recommended sample input volume of 10 mL.

Storage Conditions and Product Stability

All solutions should be kept tightly sealed and stored at room temperature. This kit is stable for 2 years after the date of shipment.

Supporting Data

Click for expanded view

Mini (50600)

Title Comparison of the Effectiveness of Four Commercial DNA Extraction Kits on Fresh and Frozen Human Milk Samples
Journal Methods Protoc. 2022.
Author Cassidy Butler, Amy Matsumoto, Casey Rutherford and Hope K. Lima
Title Optimization of DNA Extraction from Human Milk
Journal Digital Commons @ Winthrop Universtity. Spring 5-2020.
Author Cassandra Z. Rutherford.
Title Comprehensive evaluation of methods to isolate, quantify, and characterize circulating cell-free DNA from small volumes of plasma
Journal Analytical and Bioanalytical Chemistry. 2015.
Authors Mauger F, Dulary C, Daviaud C, Deleuze JF, Tost J.
Title Cow’s Milk Contamination of Human Milk Purchased via the Internet
Journal Pediatrics. 2015.
Authors Sarah A. Keim, Manjusha M. Kulkarni, Kelly McNamara, Sheela R. Geraghty, Rachael M. Billock, Rachel Ronau, Joseph S. Hogan, Jesse J. Kwiek
Title Microbial contamination of human milk purchased via the Internet
Journal Pediatrics. 2013.
Authors Keim SA, Hogan JS, McNamara KA, Gudimetla V, Dillon CE, Kwiek JJ, Geraghty SR.

Maxi (51300)

Title Loa loa and Onchocerca ochengi miRNAs detected in host circulation
Journal Molecular and Biochemical Parasitology. 2014.
Authors Lucienne Tritten, Maeghan O’Neill, Samuel Wanji, Abdel Njouendoui, Fanny Fombad, Jonas Kengne-Ouaffo, Charles Mackenzie, Timothy Geary.

Plasma/Serum Circulating DNA Purification Kits (Slurry Format)

Norgen’s Plasma/Serum Circulating DNA Purification Kits (Slurry Format) provide efficient methods for the purification of fragmented free-circulating DNA from human plasma or serum. The kit is able to isolate all sizes of circulating DNA. The slurry format provides an advantage over other available kits in that it does not require extension tubes for the purification of free-circulating DNA from large sample volumes. DNA can be isolated from either fresh or frozen samples using this kit. The kit will also isolate viral and bacterial DNA from plasma/serum. Typical yields of purified free-circulating DNA will vary depending on the input sample (1-100ng/mL circulating DNA in human plasma), with more concentrated samples tending to yield more free-circulating nucleic acids. The purified, inhibitor-free plasma/serum free-circulating DNA is eluted in an elution solution that is compatible with PCR, qPCR, methylation-sensitive PCR and Southern Blot analysis.​​

Plasma/Serum Circulating DNA Purification Mini Kit (Slurry Format)

Norgen’s Plasma/Serum Circulating DNA Purification Mini Kit (Slurry Format) provides a fast, reliable and simple procedure for isolating circulating DNA from various amounts of plasma/serum ranging from 50 μL to 400 μL. Preparation time for a single sample is less than 30 minutes.

Plasma/Serum Circulating DNA Purification Midi Kit (Slurry Format)

Norgen’s Plasma/Serum Circulating DNA Purification Midi Kit (Slurry Format) provides a fast, reliable and simple procedure for isolating circulating DNA from various amounts of plasma/serum ranging from 400 μL to 2 mL. Preparation time for a single sample is less than 45 minutes.

Plasma/Serum Circulating DNA Purification Maxi Kit (Slurry Format)

Norgen’s Plasma/Serum Circulating DNA Purification Maxi Kit (Slurry Format) provides a fast, reliable and simple procedure for isolating circulating DNA from various amounts of plasma/serum ranging from 2 mL to 10 mL. Preparation time for a single sample is less than 45 minutes.

Supporting Data

Click for expanded view

Kit Specifications

You have selected: Cat. 50600
Kit Specifications
Minimum Plasma/Serum Input
50 μL
Maximum Plasma/Serum Input
400 μL
Minimum Elution Volume
100 μL
Time to Complete Purifications
< 30 minutes


Storage Conditions and Product Stability
All solutions should be kept tightly sealed and stored at room temperature. This kit is stable for 2 years after the date of shipment.

You have selected: Cat. 51200
Kit Specifications
Minimum Plasma/Serum Input
400 μL
Maximum Plasma/Serum Input
2 mL
Minimum Elution Volume
100 μL
Time to Complete Purifications
< 45 minutes


Storage Conditions and Product Stability
It is recommended to warm Slurry C2 and Lysis Buffer A for 20 minutes at 60°C if any salt precipitation is observed. Slurry C2 contains a grey resin that will not dissolve with warming.

You have selected: Cat. 51300
Kit Specifications
Minimum Plasma/Serum Input
2 mL
Maximum Plasma/Serum Input
10 mL
Size of DNA Purified
≥ 50 bp
Elution Volume
100 μL
Time to Complete 10 Purifications
15-20 minutes
Average Yields
Variable depending on specimen

Note: Do not exceed the recommended sample input volume of 10 mL.

Storage Conditions and Product Stability

All solutions should be kept tightly sealed and stored at room temperature. This kit is stable for 2 years after the date of shipment.

Mini (50600)

Title Comparison of the Effectiveness of Four Commercial DNA Extraction Kits on Fresh and Frozen Human Milk Samples
Journal Methods Protoc. 2022.
Author Cassidy Butler, Amy Matsumoto, Casey Rutherford and Hope K. Lima
Title Optimization of DNA Extraction from Human Milk
Journal Digital Commons @ Winthrop Universtity. Spring 5-2020.
Author Cassandra Z. Rutherford.
Title Comprehensive evaluation of methods to isolate, quantify, and characterize circulating cell-free DNA from small volumes of plasma
Journal Analytical and Bioanalytical Chemistry. 2015.
Authors Mauger F, Dulary C, Daviaud C, Deleuze JF, Tost J.
Title Cow’s Milk Contamination of Human Milk Purchased via the Internet
Journal Pediatrics. 2015.
Authors Sarah A. Keim, Manjusha M. Kulkarni, Kelly McNamara, Sheela R. Geraghty, Rachael M. Billock, Rachel Ronau, Joseph S. Hogan, Jesse J. Kwiek
Title Microbial contamination of human milk purchased via the Internet
Journal Pediatrics. 2013.
Authors Keim SA, Hogan JS, McNamara KA, Gudimetla V, Dillon CE, Kwiek JJ, Geraghty SR.

Maxi (51300)

Title Loa loa and Onchocerca ochengi miRNAs detected in host circulation
Journal Molecular and Biochemical Parasitology. 2014.
Authors Lucienne Tritten, Maeghan O’Neill, Samuel Wanji, Abdel Njouendoui, Fanny Fombad, Jonas Kengne-Ouaffo, Charles Mackenzie, Timothy Geary.

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