Intact Exosome Purification

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Exosomes: The Essentials

Purify intact, functional extracellular vesicles including exosomes

  • Purification and enrichment of intact exosomes from plasma, serum, urine, cell culture media and saliva in less than 30 minutes.
  • Exosome purification is based on Norgen’s proprietary resin separating matrix through exosomes’ surface proteins.
  • No precipitation reagents, overnight incubation, protease or coagulant treatments required
  • No time-consuming ultracentrifugation, filtration or special syringes required
  • Purify intact exosomes with a size ranging from 40-200 nm depending on sample input type
  • Purified exosomes are compatible with functional studies.
  • Purified exosomes are free from any protein-bound cell-free circulating RNA
  • Purified exosomes are compatible with NanoSight® or Electron Microscopy for assessing the approximate exosome size range and concentration.
  • Exosomal RNA can be extracted from the purified exosomes using Norgen’s Exosomal RNA Purification technology or any other RNA extraction method.
cf preservative tube

Norgen’s Exosome Purification Kits enable fast, flexible, robust, and convenient intact exosome purification from a wide range of cell-free liquid biopsies and cell-free cell culture media. Relying on Norgen’s proprietary resin technology, the intact exosomes are purified in 30 minutes and are free from any cell-free circulating protein-bound RNA which typically contaminates exosomes and impedes effective exosomal content analyses. Norgen’s intact exosome purification methodology does not involve any troublesome and tedious ultracentrifugation, any chemical or immuno-precipitation techniques, any protease or coagulant treatments and doesn’t require any special equipment or overnight incubation. The purified intact exosomes are amenable to labelling, counting, imaging, and in vivo / in vitro functional studies, as well as exosomal analyte isolations and analyses.

Kits for Research Use

Cat. # Name Size  
57400, 57500, 57600 Plasma/Serum Exosome Purification Kits 50 preps, 25 preps, 15 preps View product page
57700, 57800, 57900 Urine Exosome Purification Kits 50 preps, 25 preps, 10 preps View product page
60400, 60500, 60600 Cell Culture Media Exosome Purification Kits 50 preps, 25 preps, 15 preps View product page
65300 Saliva Exosome Purification Kit 50 preps View product page
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Purify intact, functional extracellular vesicles including exosomes