Extract the highest quality & quantity of true total RNA, including microRNA, without the use of phenol

Best-in-Class Total RNA Extraction Technology

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Best-in-Class RNA Extraction Technology

Norgen vs competitor

Why Norgen's RNA Extraction Technology is Best-in-Class

  1. No Hazardous Compounds - Phenol/chloroform is a hazardous compound used in many RNA isolation kits and carryover from the isolation step can affect sensitive downstream applications such as PCR and next generation sequencing (NGS) due to its inhibitory effects on reverse transcriptase. This can lead to low quality results and even missed diagnosis. Norgen's industry leading proprietary technology avoids the use of phenol/chloroform and other hazardous organic compounds all together eliminating any worry about the impact of phenol/chloroform carryover.

  2. Size (and Content) Matters - Not all RNA strands were created equal in length - size matters! Popular RNA isolation kits that use silica have clearly demonstrated to have a preference towards binding large RNA species. Norgen's industry-leading technology has demonstrated best-in-class capture of the true total RNA content of the sample with no bias, including the most diverse collection of micro RNAs. Additionally, silica-based RNA isolations have also shown a bias towards high GC content RNA strands, which has consequently caused important papers to be retracted due to the biased findings. Norgen's proprietary technology has demonstrated to have no bias toward high GC content species and therefore captures a more accurate picture of the true total RNA content of the sample.

  3. Sensitive Results Need Sensitive Tests - When it comes to obtaining a critical RNA isolation result there is no better RNA technology to trust than Norgen. In a paper published during the COVID pandemic Norgen's proprietary RNA isolation technology was shown to be superior to competitors in detecting early phase infection, successfully detecting COVID in 100% of the positive samples whereas the silica-based competitor only detected 25%. Additionally, experiments have shown that our RNA technology remains linear in it's yield with logarithmic decreases in cell concentration whereas competitors drop off at low concentrations without the use of RNA carriers. This becomes an issue with downstream applications such as sequencing efficiency.

Supporting Data

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Shop RNA Extraction Kits

Showing 7 of 7 products
Total RNA Purification Kit Dx

Total RNA Purification Kit Dx

(Dx17200, Dx24300, Dx24350, Dx24380)

For the extraction of total RNA from tissue samples, blood, plasma, serum, bacteria, yeast, fungi and viruses for subsequent in vitro diagnostic use

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Total RNA Purification Kit

Total RNA Purification Kit

(17200, 37500, 17250, 17270, 24300, 24350, 24370, 24380)

For the rapid extraction of total RNA - including microRNA - without the use of phenol

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Total RNA Purification Plus Kit

Total RNA Purification Plus Kit

(48300, 48400)

For the extraction of total RNA - including microRNA - with rapid gDNA removal

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Total RNA Purification Micro Kit

Total RNA Purification Micro Kit

(35300, 35350)

Rapid extraction of total RNA - including microRNA - from small input amounts

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Total RNA Purification Plus Micro Kit

Total RNA Purification Plus Micro Kit

(48500)

Rapid extraction of total RNA - including microRNA - from small input amounts

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Total RNA Purification Maxi Kit

Total RNA Purification Maxi Kit

(26800)

For the rapid extraction of total RNA - including microRNA - without the use of phenol

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Single Cell RNA Purification Kit

Single Cell RNA Purification Kit

(51800)

Rapid extraction of total RNA - including microRNA - from small input amounts

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What our customers like about our kits

Select Publications

Title Combined MEK and JAK/STAT3 pathway inhibition effectively decreases SHH medulloblastoma tumor progression
Journal Communications Biology
Authors Zagozewski, J.; Borlase, S.; Guppy, B.J.; et al.
Title A nuclear function for an oncogenic microRNA as a modulator of snRNA and splicing
Journal Molecular Cancer
Authors El Fatimy, R.; Zhang, Y.; Deforzh, E.; et al.
Title Multiomic analysis of microRNA-mediated regulation reveals a proliferative axis involving miR-10b in fibrolamellar carcinoma
Journal JCI Insight
Authors Francisco, A.; Kanke, M.; Massa, A.; et al.
Title Blood circulating miR-28-5p and let-7d-5p associate with premature ageing in Down syndrome
Journal Science Direct
Authors Morsiani, C.; Bacalini, M.G.; Collura, S.; et al.
Title Contributions of Circulating microRNAs for Early Detection of Lung Cancer
Journal Cancers 2022
Authors Vykoukal, J.; Fahrmann, J.F.; Patel, N.; et al.
Title Synergistic Analysis of Circulating Tumor Cells Reveals Prognostic Signatures in Pilot Study of Treatment-Naïve Metastatic Pancreatic Cancer Patients
Journal Biomedicines 2022
Authors Owen, S.; Prantzalos, E.; Gunchick, V.; et al.
Title Validation of Isolation Methodology and Endogenous Control Selection for qRT-PCR Assessment of Microrna Expression in Serum and Urine Exosomes
Journal Blood 2014
Authors Crossland, R.E.; Norden, J.; Bibby, L.; et al.
Title Evaluation of different RNA extraction methods for high-quality total RNA and mRNA from Erwinia amylovora in planta
Journal European Journal of Plant Pathology 2016
Authors Kałużna, M.; Kuras, A.; Mikiciński, A.; Puławska, J.
Title Comparison of Whole Blood RNA Preservation Tubes and Novel Generation RNA Extraction Kits for Analysis of mRNA and MiRNA Profiles
Journal PLOS ONE 2014
Authors Häntzsch, M.; Tolios, A.; Beutner, F.; Nagel, D.; Thiery, J.; et al.
Title Simultaneous extraction of mRNA and microRNA from whole blood stabilized in tempus tubes
Journal BMC Res Notes 2019
Authors Richards, J.; Unger, E.R.; Rajeevan, M.S.
Title Total RNA extraction from tissues for microRNA and target gene expression analysis: not all kits are created equal
Journal BMC Biotechnology 2018
Authors Brown, R.A.M.; Epis, M.R.; Horsham, J.L.; et al.

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Norgen's Best-in-Class RNA Extraction Technology

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NGS Technician

Next Generation Sequencing
Sequence from Ultra Low Inputs using the Illumina Platform