Urine Collection and Preservation Devices

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Complete Urine Workflow

Urine Collection and Preservation Devices

Best-in-class solutions for rapid collection and preservation of urine samples

Featured Publication: IgA nephropathy is associated with elevated urinary mitochondrial DNA copy numbers.
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  cf-DNA/cf-RNA Preservative Tube
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Urine Collection and Preservation Devices

Select each molecule to learn more about Norgen's unique tube and how it separates DNA/RNA from urine samples

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cf-DNAcf-DNA×
cf-RNAcf-RNA×
Cellular g-DNACellular g-DNA×
ExosomeExosome×
Micro RNAMicro RNA×
ProteinProtein×
Cellular RNA×
Urine Preservative Cup
cf-DNA
cf-DNA
cf-RNA
cf-RNA
Cellular g-DNA
Cellular g-DNA
Exosomes
Exosome
Micro RNA
Micro RNA
Protein
Protein
Cellular RNA
Cellular RNA

Urine Collection and Preservation Devices

Norgen's Urine Collection and Preservation Devices provide a rapid and simple method for the collection, preservation and shipping of urine samples. The Urine Preservative eliminates the need to immediately process or freeze samples and allows the samples to be shipped to centralized testing facilities at ambient temperatures. Nucleic acids and proteins are preserved for more than 2 years at room temperature. Compatible with most DNA/RNA isolation methods.

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cf-DNA

cf-DNA

Recent evidence indicates that cell-free circulating DNA (cf-DNA) contains valuable information for the discovery of biomarkers that can help with early detection of certain cancer types and for monitoring the disease status. The advantage for using urine as a source for cancer biomarkers is that it can be acquired in large quantities without using invasive procedures. In addition, repeated sampling from the same individual is applicable, which facilitates longitudinal studies. Urine cell-free circulating DNA (cf-DNA) has been utilized for the early diagnosis, prognosis and monitoring of therapy for several cancer types and autoimmune diseases, as well as for investigating fetal DNA that is normally present in the maternal blood. This cf-DNA is usually present as short fragments, generally between 150 and 250 bp or its duplicates, and is derived either from the apoptotic process, necrotic process or from the fetus.

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× cf-RNA

cf-RNA

Recent evidence indicates that cell-free circulating RNA (cf-RNA) including exosomal RNA in urine contains valuable information for the discovery of biomarkers that can help for the early detection of certain cancer types and for monitoring the disease status as well as for the detection of any infectious pathogens. Cell-free RNA may serve as biomarkers for various diseases including cancer.

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Cellular g-DNA

Many advantages favor the use of urinary DNA for cancer biomarker discovery and diagnosis of different pathogens over the use of blood and tissue samples. DNA found in urine can be divided into 2 basic categories, large, and small. The larger genomic DNA (gDNA) species is generally greater than 1 kb in size, and appears to be derived mainly from exfoliated cells. The second species is smaller, generally between 150 and 250 bp (apoptotic-DNA), and derives, at least in part, from the circulation. The second species is also considered as an RNA/DNA hybrid.

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× Exosomes under microscope Exosome

Exosome

Exosomes are small extracellular vesicles released from cells throughout the body. They are typically between 40-150nm in diameter and act as cellular "messengers", carrying their cargo of proteins, lipids, and cell-free nucleic acids throughout the bloodstream to recipient cells. Since exosomes are released from a variety of cell types, including tumor cells, analyzing their content can provide unique biomarkers for various diseases.

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× Micro RNA

Micro RNA

Small RNA molecules are often studied due to their ability to regulate gene expression. miRNAs are typically 20-25 nucleotides long, and regulate gene expression by binding to mRNA molecules and affecting their stability or translation. Several recent studies showed that miRNA regulates cell growth and apoptosis.

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hand pointing × Proteins

Proteins

Urinary proteins are important for many applications such as biomarker discovery, differential expression of proteins in various diseases, and diagnosis. Proper protein concentration prepares the molecules for downstream applications including SDS-PAGE, 2D gels, Whole protein mass spectrometry, MALDI-TOF, LC/MS, Western blotting and Protein microarray.

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× Cellular RNA

Cellular RNA

Urine contains various sizes of RNA; from large mRNA and ribosomal RNA down to small RNAs. These small RNAs include regulatory RNA molecules such as microRNA (miRNA) as well as tRNA and 5S rRNA.

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Features & Benefits

  • RNA/microRNA/DNA/Proteins are preserved for more than 2 years at room temperature in Norgen's Urine Preservative
  • Compatible with most DNA, Total RNA, microRNA and protein isolation methods
  • Preservative is available in a single dose liquid format (ampoule)
  • Preservative is also available in a dried format in tubes - Urine Collection and Preservation Tubes
  • Convenient and useful for preserving cell-free macromolecules as well as exfoliated cells and microorganisms during shipping of urine at ambient temperatures

Supporting Data

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Isolate High Quality RNA and DNA from Urine Samples

Use the interactive workflow to find the product right for you

Fresh Or Frozen Urine Sample

  1. Whole Urine

    1. Total RNA

      Purify high quality total RNA of all sizes from urine

    2. Total DNA

      Isolate high quality total DNA of all sizes from urine

    3. Cell Pellet

      Isolate high quality RNA or DNA from exfoliated cells or bacteria from urine

  2. Cell-free Urine

    1. cf-RNA

      Purify high quality cell-free circulating and exosomal RNA from urine

    2. cf-DNA

      Isolate high quality cell-free circulating DNA from urine

    3. cfc-Nucleic Acids

      Purify high quality cell-free circulating DNA and cell-free circulating RNA from urine

    4. Exosomes

      Purify high quality intact exosomes from urine

  1. Total RNA

    Purify high quality total RNA of all sizes from urine

    1. Urine MicroRNA Purification Kit (Cat. 29000)

      Input Vol Range: 0.5 - 1 mL

    2. Urine Total RNA Purification (slurry) format (Cat. 29600)

      Input Vol Range: 5 - 10 mL

    3. Urine Total RNA Purification 96-well format (Cat. 29650)

      Input Vol Range: 5 - 10 mL

  1. Total DNA

    Isolate high quality total DNA of all sizes from urine

    1. Urine DNA Isolation Kit (Cat. 18100)

      Input Vol Range: 50 µL to 1.75 mL

    2. Urine DNA Isolation (Slurry format) - (Cat. 48800)

      Input Vol Range: 3 mL to 25 mL

    3. Urine DNA Isolation Maxi Kit (Slurry format) - (Cat. 50100)

      Input Vol Range: 25 mL to 80 mL

  1. Cell pellet

    Isolate high quality RNA or DNA from exfoliated cells or bacteria from urine

    1. Urine Exfoliated Cell RNA Purification Kit (Cat. 22550)

      Input Vol Range: 1 mL to 50 mL

    2. Urine DNA Isolation Kit for Exfoliated Cells or Bacteria (Cat. 47050)

      Input Vol Range: 1 mL to 50 mL

  1. cf-RNA

    Purify high quality cell-free circulating and exosomal RNA from urine

    1. Urine Cell-Free Circulating RNA Purification Mini Kit (Cat. 56900)

      Input Vol Range: 250 μL to 2 mL

    2. Urine Cell-Free Circulating RNA Purification Midi Kit (Cat. 57000)

      Input Vol Range: 2 mL to 10 mL

    3. Urine Cell-Free Circulating RNA Purification Maxi Kit (Cat. 57100)

      Input Vol Range: 10 mL to 30 mL

  1. cf-DNA

    Isolate high quality cell-free circulating DNA from urine

    1. Urine Cell-Free Circulating DNA Purification Mini Kit (Cat. 56600)

      Input Vol Range: 250 µL to 2 mL

    2. Urine Cell-Free Circulating DNA Purification Midi Kit (Cat. 56700)

      Input Vol Range: 2 mL to 10 mL

    3. Urine Cell-Free Circulating DNA Purification Maxi Kit (Cat. 56800)

      Input Vol Range: 10 mL - 30 mL

  1. cfc-Nucleic Acids

    Purify high quality cell-free circulating DNA and cell-free circulating RNA from urine

    1. Urine Cell-Free Circulating and Viral Nucleic Acid Purification Mini Kit (Cat. 59900)

      Input Vol Range: 250 µL to 2 mL

    2. Urine Cell-Free Circulating and Viral Nucleic Acid Purification Midi Kit (Cat. 60000)

      Input Vol Range: 2 mL - 10 mL

    3. Urine Cell-Free Circulating and Viral Nucleic Acid Purification Maxi Kit (Cat. 60100)

      Input Vol Range: 10 mL - 30 mL

  1. Urine Exosome Purification and RNA Isolation Kits

    (Cat. 58400, 58700, 58800)

    1. Urine Exosome Purification and RNA Isolation Mini Kit (Cat. 58400)

      Input Vol Range: 250 µL to 1 mL

    2. Urine Exosome Purification and RNA Isolation Midi Kit (Cat. 58700)

      Input Vol Range: 2 mL to 10 mL

    3. Urine Exosome Purification and RNA Isolation Maxi Kit (Cat. 58800)

      Input Vol Range: 11 mL to 30 mL

  1. Urine Exosome and Free-Circulating RNA Isolation Kits

    (Cat. 59200, 59300, 59400)

    1. Urine Exosome and Free-Circulating RNA Isolation Mini Kit (Cat. 59200)

      Input Vol Range: 250 µL to 1 mL

    2. Urine Exosome and Free-Circulating RNA Isolation Midi Kit (Cat. 59300)

      Input Vol Range: 2 mL to 10 mL

    3. Urine Exosome and Free-Circulating RNA Isolation Maxi Kit (Cat. 59400)

      Input Vol Range: 11 mL to 30 mL

  1. Urine Exosome Purification Kits

    (Cat. 57700, 57800, 57900)

    1. Urine Exosome Purification Mini Kit (Cat. 57700)

      Input Vol Range: 250 µL to 1 mL

    2. Urine Exosome Purification Midi Kit (Cat. 57800)

      Input Vol Range: 2 mL to 10 mL

    3. Urine Exosome Purification Maxi Kit (Cat. 57900)

      Input Vol Range: 11 mL to 30 mL

Fresh or frozen Urine Sample

  1. Whole Urine

    1. Total RNA

      Purifies total RNA from urine

      1. Urine MicroRNA Purification Kit (Cat. 29000)

        Input Vol Range: 0.5 - 1 mL

      2. Urine Total RNA Purification (slurry) format (Cat. 29600)

        Input Vol Range: 5 - 10 mL

      3. Urine Total RNA Purification 96-well format (Cat. 29650)

        Input Vol Range: 5 - 10 mL

    2. Total DNA

      Isolates total DNA from urine

      1. Urine DNA Isolation Kit (Cat. 18100)

        Input Vol Range: 50 µL to 1.75 mL

      2. Urine DNA Isolation (Slurry format) - (Cat. 48800)

        Input Vol Range: 3 mL to 25 mL

      3. Urine DNA Isolation Maxi Kit (Slurry format) - (Cat. 50100)

        Input Vol Range: 25 mL to 80 mL

    3. Cell Pellet

      Isolates and purifies total RNA and total DNA from urine

      1. Urine Exfoliated Cell RNA Purification Kit (Cat.22550)

        Input Vol Range: 1 mL to 50 mL

      2. Urine DNA Isolation Kit for Exfoliated Cells or Bacteria (Cat. 47050)

        Input Vol Range: 1 mL to 50 mL

  2. Cell-free Urine

    1. cf-RNA

      Purifies and concentrates cf circulating RNA from urine

      1. Urine Cell-Free Circulating RNA Purification Mini Kit (Cat. 56900)

        Input Vol Range: 250 μL to 2 mL

      2. Urine Cell-Free Circulating RNA Purification Midi Kit (Cat. 57000)

        Input Vol Range: 2 mL to 10 mL

      3. Urine Cell-Free Circulating RNA Purification Maxi Kit (Cat. 57100)

        Input Vol Range: 10 mL to 30 mL

    2. cf-DNA

      Isolates and concentrates cf circulating DNA from urine

      1. Urine Cell-Free Circulating DNA Purification Mini Kit (Cat. 56600)

        Input Vol Range: 250 µL to 2 mL

      2. Urine Cell-Free Circulating DNA Purification Midi Kit (Cat. 56700)

        Input Vol Range: 2 mL to 10 mL

      3. Urine Cell-Free Circulating DNA Purification Maxi Kit (Cat. 56800)

        Input Vol Range: 10 mL - 30 mL

    3. cfc- Nucleic Acids

      Purifies and concentrates both cf circulating DNA & circulating RNA urine

      1. Urine Cell-Free Circulating and Viral Nucleic Acid Purification Mini Kit (Cat. 59900)

        Input Vol Range: 250 µL to 2 mL

      2. Urine Cell-Free Circulating and Viral Nucleic Acid Purification Midi Kit (Cat. 60000)

        Input Vol Range: 2 mL - 10 mL

      3. Urine Cell-Free Circulating and Viral Nucleic Acid Purification Maxi Kit (Cat. 60100)

        Input Vol Range: 10 mL - 30 mL

    4. Exosomes

      Purify high quality intact exosomes from urine

      1. Urine Exosome RNA Isolation Kit (Cat. 47200)

        Input Vol Range: 1 mL to 10 mL

      2. Urine Exosome Purification and RNA Isolation Mini Kit (Cat. 58400)

        Input Vol Range: 250 µL to 1 mL

      3. Urine Exosome Purification and RNA Isolation Midi Kit (Cat. 58700)

        Input Vol Range: 2 mL to 10 mL

      4. Urine Exosome Purification and RNA Isolation Maxi Kit (Cat. 58800)

        Input Vol Range: 11 ml to 30 mL

      5. Urine Exosome and Free-Circulating RNA Isolation Mini Kit (Cat. 59200)

        Input Vol Range: 250 µL to 1 mL

      6. Urine Exosome and Free-Circulating RNA Isolation Midi Kit (Cat. 59300)

        Input Vol Range: 2 mL to 10 mL

      7. Urine Exosome and Free-Circulating RNA Isolation Maxi Kit (Cat. 59400)

        Input Vol Range: 11 ml to 30 mL

      8. Urine Exosome Purification Mini Kit (Cat. 57700)

        Input Vol Range: 250 µL to 1 mL

      9. Urine Exosome Purification Midi Kit (Cat. 57800)

        Input Vol Range: 2 mL to 10 mL

      10. Urine Exosome Purification Maxi Kit (Cat. 57900)

        Input Vol Range: 11 ml to 30 mL

Norgen Cell-Free RNA Purification Kits

Cell-Free RNA Purification Kits

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Norgen Cell-Free DNA Purification Kits

Cell-Free DNA Purification Kits

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Norgen Cell-Free Multi-Analyte Purification Kits

Cell-Free Multi-Analyte Purification Kits

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Norgen Exosome Purification and RNA Isolation Kits

Exosome Purification and RNA Isolation Kits

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Norgen Total RNA Kits

Total RNA Kits

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Norgen Total DNA Kits

Total DNA Kits

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Discover Norgen's NGS Services and Capture the Most From Your Samples

Next Generation Sequencing

Designed to Discover

Sequence Ultra-low Inputs from Plasma/Serum, Exosomes and More with Norgen's Small RNA-Seq Services.

  • Capture a Complete Range of Small RNA and miRNA species
  • Sequence Ultra-Low Inputs from Liquid Biopsies and Exosomes
  • Illumina® NextSeq Sequencing Platform
  • Understand Post-Transcriptional Regulation with Bioinformatics Analysis Service
  • Examine Differential Expression and Discover Novel Biomarkers
  • Fast Turn Around Time | 3 - 4 weeks
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Featured Publications

Featured
Title Extracellular circular RNA profiles in plasma and urine of healthy, male college athletes
Journal Scientific Data volume 8, Article number: 276. 2021.
Authors Hutchins, E., Reiman, R., Winarta, J. et al.
Title Comparison of Four Commercial Kits for Isolation of Urinary Cell-Free DNA and Sample Storage Conditions
Journal Diagnostics 2020, 10(4), 234.2020
Authors Lee, E.Y.; Lee, E.-J.; Yoon, H.; Lee, D.H.; Kim, K.H.
Title IgA nephropathy is associated with elevated urinary mitochondrial DNA copy numbers
Journal Scientific Reports volume 9, Article number: 16068. 2019.
Authors Yu, B.C., Cho, NJ., Park, S. et al.
Title Comparison of MicroRNA Content in Plasma and Urine Indicates the Existence of a Transrenal Passage of Selected MicroRNAs
Journal Adv Exp Med Biol;924:97-100.. 2016.
Authors Pazourkova, E. et al.
Title Mass Spectrometric Quantification of Urinary Netrin-1 Protein in Renal Transplant Recipients
Journal Current Proteomics, Volume 13, Number 1, 2016, pp. 31-38(8). 2016.
Authors Ozcan, Filiz; Akbas, Halide; Suleymanlar, Gultekin; Aslan, Mutay; Yucel, Gultekin
Title Characterization and deep sequencing analysis of exosomal and non-exosomal miRNA in human urine
Journal TECHNICAL NOTES| VOLUME 86, ISSUE 2, P433-444. AUGUST 01, 2014
Authors Cheng, L., Sun, X., Scicluna, B.J., Coleman, B., Hill, A.

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